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Cytochalasans, a new class of sphinganines produced by a saprophytic strain of the fungus, Cytochalasium ulei.
Cytochalasans, a new class of sphinganines, were isolated and characterized from a saprophytic strain of the basidiomycete fungus, Cytochalasium ulei. The structure of the major compound (1) was elucidated by extensive 1D and 2D NMR, and MS studies. Cytochalasans showed a weak anti-proliferative activity on CCRF-CEM human leukemia cells.[The effects of etomidate, propofol, ketamine, lidocaine, and thiopental on cochlear microcirculation].
To investigate the effects of etomidate, propofol, ketamine, lidocaine and thiopental on cochlear microcirculation. Twenty-four guinea pigs (340 - 420 g) were randomized into four groups: ET (etomidate), PT (propofol), KT (ketamine), LT (lidocaine), and TH (thiopental). Fifty microliters of blood was drawn by the capillary tube (lumen 140 mu) from the right external jugular vein to measure the vascular diameter. The right cochlea of each animal was exposed, after the operation of the tympanic membrane was completed. In the ET group, cochlear blood flow (CBF) was measured every 5 minutes for 60 minutes, after which anesthesia was maintained for 60 minutes. In the PT group, CBF was measured every 5 minutes for 60 minutes, and then anesthesia was maintained for 60 minutes. In the KT group, CBF was measured every 5 minutes for 60 minutes and then anesthesia was maintained for 60 minutes. In the LT group, CBF was measured every 5 minutes for 60 minutes, and then anesthesia was maintained for 60 minutes. In the TH group, CBF was measured every 5 minutes for 60 minutes, and then be359ba680
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